Successful Re-administration of Granulocyte Colony-Stimulating Factor Without Recurrence of Associated Vasculitis: A...

We report a case of diffuse large B-cell lymphoma complicated by granulocyte colony-stimulating factor (G-CSF)-associated vasculitis following filgrastim administration. The vasculitis resolved with corticosteroid therapy, and maintenance treatment was continued long-term. During salvage chemotherapy for lymphoma relapse 14 months after the initial episode, G-CSF was reintroduced because of persistent myelosuppression. Filgrastim and pegfilgrastim were used in subsequent cycles without recurrence of vasculitis. This case suggests that G-CSF re-administration may be cautiously considered on an individual basis, particularly when vasculitis is well controlled with corticosteroids and a sufficient interval has elapsed. These findings may help guide individualized management in similar clinical situations.