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Hypercalcemia in Patients After Kidney Transplantation.
Miłosz Miedziaszczyk1, Katarzyna Lacka2, Aleksander Bajon3
1Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, Poznan, POL.
Cureus
|November 24, 2025
Summary
Hypercalcemia is common after kidney transplantation (KTx), affecting nearly 20% of patients. While calcium levels increased over three years, no significant impact on kidney graft function was found.
Area of Science:
- Nephrology
- Endocrinology
- Transplantation Medicine
Background:
- Mineral and bone disorders are frequent complications of chronic kidney disease (CKD).
- Persistent hyperparathyroidism post-kidney transplantation (KTx) can lead to hypercalcemia, potentially impairing graft function.
- Hypercalcemia is a known complication that requires monitoring in KTx recipients.
Purpose of the Study:
- To determine the prevalence of hypercalcemia within three years post-KTx.
- To evaluate the impact of hypercalcemia on renal graft filtration function.
- To assess trends in calcium levels following KTx.
Main Methods:
- Retrospective study including 84 kidney transplant recipients.
- Measurement of total calcium and creatinine levels at one, two, and three years post-transplantation.
- Statistical analysis using MedCalc software.
Main Results:
- Hypercalcemia prevalence was 19.1% at year one, 16.7% at year two, and 20.2% at year three.
- A statistically significant increase in total and ionized calcium levels was observed over the three-year period.
- No significant correlation was found between ionized calcium and serum creatinine or estimated glomerular filtration rate (eGFR).
Conclusions:
- Hypercalcemia is a common occurrence after KTx, with increasing calcium levels over time.
- No significant association between hypercalcemia and impaired graft function was identified in this study.
- Routine monitoring for hypercalcemia and hyperparathyroidism is recommended for kidney transplant recipients, aligning with KDIGO guidelines.
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