Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

50.4K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
50.4K
Hair Cells01:22

Hair Cells

44.3K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
44.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In vivo</i> evidence of outer hair cell length changes and their role in high-frequency cochlear mechanics.

Frontiers in audiology and otology·2026
Same author

Anatomical Integrity of the Human Cochlea Estimated with Optical Coherence Tomography for Future Clinical Application.

Journal of the Association for Research in Otolaryngology : JARO·2025
Same author

Simulation-based inference for subject-specific tuning of middle ear finite-element models towards personalized objective diagnosis.

Scientific reports·2025
Same author

Anatomical integrity of the human cochlea estimated with optical coherence tomography for future clinical application.

bioRxiv : the preprint server for biology·2025
Same author

Simplified Vocal Efficiency Metrics Normalize Following Voice Therapy in Subgroups of Patients With Nonphonotraumatic Vocal Hyperfunction.

American journal of speech-language pathology·2025
Same author

Evaluation of thin-slice finite-element models for 3D cochlear organ of Corti mechanics.

Hearing research·2025

Related Experiment Video

Updated: Jan 10, 2026

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

12.5K

UTILIZING INFORMATION THEORETIC APPROACH TO STUDY COCHLEAR NEURAL DEGENERATION.

Ahsan J Cheema1,2, Sunil Puria1,2

  • 1Harvard University, Speech and Hearing Bioscience and Technology Program, Boston MA, USA.

Arxiv
|November 24, 2025
PubMed
Summary
This summary is machine-generated.

Hidden hearing loss (cochlear neural degeneration) impairs speech understanding without changing hearing test results. Rapid speech is best for detecting this condition, unlike reverberation.

Keywords:
cochlear synaptopathyhearing aidshearing lossinformation theorymutual information

More Related Videos

Cochlear Surface Preparation in the Adult Mouse
09:51

Cochlear Surface Preparation in the Adult Mouse

Published on: November 6, 2019

17.2K
Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
08:30

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

Published on: June 8, 2017

18.6K

Related Experiment Videos

Last Updated: Jan 10, 2026

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

12.5K
Cochlear Surface Preparation in the Adult Mouse
09:51

Cochlear Surface Preparation in the Adult Mouse

Published on: November 6, 2019

17.2K
Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
08:30

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

Published on: June 8, 2017

18.6K

Area of Science:

  • Auditory Neuroscience
  • Speech Processing
  • Information Theory

Background:

  • Hidden hearing loss, or cochlear neural degeneration (CND), affects suprathreshold auditory coding but not clinical hearing thresholds.
  • CND diagnosis is challenging due to its subtle effects on auditory processing.

Purpose of the Study:

  • To develop an information-theoretic framework to identify speech stimuli that best reveal CND.
  • To quantify mutual information (MI) loss between auditory system components under varying CND conditions.

Main Methods:

  • Utilized a phenomenological auditory model to simulate neural responses to speech stimuli.
  • Varied CND levels by simulating different spontaneous-rate fiber survival rates.
  • Analyzed MI between inner hair cell (IHC) potentials and auditory nerve fiber (ANF) responses, and acoustic input and ANF responses.

Main Results:

  • Demonstrated progressive MI loss with increasing CND.
  • Identified time-compressed speech as the most sensitive stimulus for revealing MI loss.
  • Reverberation showed less impact on MI loss compared to temporal compression.

Conclusions:

  • Rapid, temporally dense speech stimuli are optimal for detecting CND.
  • Findings can inform the development of objective clinical diagnostic tools for hidden hearing loss.
  • Highlights limitations of reverberation as a probe for CND.