A Case Series on Regenerative Endodontic Treatment: Clinical Applications and Outcomes

Regenerative endodontic treatment (RET) promotes tissue regeneration and root development in immature necrotic teeth. This case series examines RET outcomes in varied cases, including immature and mature teeth with periapical pathology, failed root canal treatments, large cyst-like lesions, and internal inflammatory root resorption. Five cases were treated using standardized RET protocols, including sodium hypochlorite and ethylenediaminetetraacetic acid irrigation, intracanal medicaments, and biological scaffolds (blood clot, platelet-rich plasma, and platelet-rich fibrin). Canals were sealed with biocompatible materials, followed by clinical and radiographic monitoring. All patients remained asymptomatic, with radiographic evidence of periapical healing. Some teeth showed canal narrowing due to calcific tissue deposition. Despite the absence of pulp sensibility responses, all cases demonstrated successful healing. RET is a promising, versatile approach for managing complex endodontic conditions. Success depends on effective disinfection, scaffold selection, and individualized planning. Continued research and protocol refinement are essential for broader clinical application.