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Updated: Jan 10, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Cellular Senescence in Endometrium: A Pivotal Regulator in Physiological Remodeling and Pathological Disorders
Zi-Yang Yan1,2, Wen-Jie Zhou3, Jiang-Feng Ye4
1Department of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
None:
As a highly dynamic tissue, the endometrium undergoes complex remodeling during the menstrual cycle and pregnancy. Recent studies have revealed that cellular senescence plays a pivotal role in both physiological renewal (e.g., menstrual shedding, decidualization) and pathological disorders (e.g., endometriosis, intrauterine adhesions, thin endometrium) of the endometrium. Under physiological conditions, senescent cells contribute to tissue repair and embryo implantation through precise regulation. However, pathological accumulation of senescent cells drives chronic inflammation, fibrosis, and reproductive dysfunction. Here we aim to summarize the mechanism indicating endometrial senescence and elucidating their pleiotropic roles in both physiological homeostasis and pathological progression, while discussing emerging therapeutic strategies for clinical translation-including senolytics and SASP inhibitors.
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