Related Experiment Video
Updated: Jan 10, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Recurrent Familial Normophosphatemic Tumoral Calcinosis: A Case Report
Shibanand Buddhia1, Tushar Ranjan Dalei1, Kumud Badhu Sahoo2
1Department of Orthopaedics, Veer Surendra Sai Institute of Medical Sciences and Research, Sambalpur, Odisha, India.
Introduction:
Tumoral calcinosis (TC) is a rare disorder characterized by periarticular soft-tissue deposition of calcium around large joints.
Case Report:
We report a recurrent familial case of a 63-year-old Indian female with progressive painless discharging mass over the left proximal thigh associated with extensive ophthalmological involvement in the form of perilimbal calcific deposits, angioid streak, pigment epithelial defects, and choroidal neovascular membrane in both eyes. Hematological parameters revealed normophosphatemic. Radiological investigation suggested periarticular calcific deposits with sedimentation sign, and the diagnosis was later confirmed on histopathological examination.
Conclusion:
We report the case because of its rarity and suggest thorough ophthalmological and genetic evaluation in each and every patient of TC.
Related Concept Videos
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

