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Updated: Jan 10, 2026
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Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
Published on: July 18, 2025
750
A self-locking conductive cardiac patch for immediate electrical integration with infarcted rat myocardium
Mengqi Shan1,2,3, Yimeng Li1,2,3, Leqian Wei1,2,3
1Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China.
Bioactive Materials
|November 24, 2025
Summary
A novel conductive patch with microneedles (CBMN-CP) effectively repairs myocardial infarction (MI) by ensuring immediate electrical integration. This innovation improves cardiac function and promotes healing in heart attack models.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cardiovascular Research
Background:
- Myocardial infarction (MI) is a leading cause of mortality worldwide.
- Conductive patches offer potential for MI repair but face challenges in electrical integration with the myocardium due to the epicardium and scar tissue.
- Immediate and effective electrical connection between the patch and host tissue is crucial for successful MI repair.
Purpose of the Study:
- To develop and evaluate a conductive barbed microneedle-integrated conductive patch (CBMN-CP) for enhanced myocardial repair.
- To overcome the limitations of traditional conductive patches in achieving immediate electrical integration with the myocardium.
- To assess the efficacy of CBMN-CP in improving cardiac function and myocardial repair post-MI.
Main Methods:
- Development of a conductive patch integrated with barbed microneedles (CBMN-CP).
- Utilizing a rat myocardial infarction model to test CBMN-CP performance.
- Comparative analysis of CBMN-CP against traditional conductive patches.
- Assessment of cardiac function, myocardial repair, angiogenesis, and inflammatory responses.
- RNA sequencing to analyze gene expression changes mediated by CBMN-CP.
Main Results:
- CBMN-CP demonstrated robust self-anchoring and penetration of the epicardium into the myocardium.
- The patch successfully bridged non-infarcted myocardium across the infarcted area, re-establishing electrical pathways.
- CBMN-CP significantly improved early cardiac function on day 3 post-infarction compared to traditional patches.
- Enhanced myocardial repair was observed, including re-established electrical connections, promoted angiogenesis, and regulated inflammatory responses.
- RNA sequencing revealed CBMN-CP modulates cardiac function via genes related to early cardiac conduction and calcium handling.
Conclusions:
- The CBMN-CP strategy provides immediate electrical integration for myocardial repair.
- This innovative approach significantly enhances early cardiac function and promotes myocardial healing post-MI.
- CBMN-CP shows considerable promise for practical applications in treating myocardial infarction.
Keywords:
Conductive patchesImmediate electrical integrationMicroneedlesMyocardial repairSelf-locking
