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Updated: Jan 10, 2026

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Long COVID: Lung Pathophysiology and its Relationship with Cognitive Dysfunction.

Keegan R Staab¹, Marrissa J McIntosh¹, Abhilash S Kizhakke Puliyakote¹

¹University of Iowa.

Research Square

|November 24, 2025

Summary

Long COVID can cause lasting cognitive issues linked to lung problems. Impaired lung gas exchange in Long COVID patients correlated with sleep issues and cognitive deficits, suggesting a connection.

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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

Area of Science:

Neurology
Pulmonology
Radiology

Background:

Post-acute sequelae of COVID-19 (Long COVID) presents with persistent physical and cognitive symptoms.
The relationship between lung pathophysiology and cognitive dysfunction in Long COVID is not well understood.

Purpose of the Study:

To explore the links between lung function and cognitive performance in individuals with Long COVID.
To investigate correlations between pulmonary gas exchange, brain imaging findings, and cognitive symptoms.

Main Methods:

Recruited Long COVID participants from a post-COVID-19 clinic.
Utilized PROMIS questionnaires, NIHTB-CB, pulmonary function tests, structural/functional brain MRI, and 129Xe MRI.
Assessed bivariate relationships using Spearman partial correlations adjusted for age.

Main Results:

PROMIS scores revealed significant fatigue, anxiety, depression, sleep disturbance, and reduced perceived cognitive function.
Objective cognitive performance on NIHTB-CB was generally within normal limits.
Reduced 129Xe MRI gas exchange correlated with increased sleep disturbance, executive dysfunction, and elevated cerebral perfusion.

Conclusions:

Findings suggest a link between lung pathophysiology and cognitive dysfunction in Long COVID.
Enduring respiratory and cognitive symptoms in Long COVID patients may be interconnected.
Further research is warranted to elucidate the mechanisms underlying these associations.