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Changes in hemispheric dominance following targeted muscle reinnervation: a case study

Toka Mootaz AboElnour1, Kaitlin Fraser Wilsey1, Kai Yang2

  • 1Additive Manufacturing Laboratory, Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, United States.

Frontiers in Human Neuroscience
|November 24, 2025
PubMed
Summary

Targeted muscle reinnervation (TMR) surgery reduces phantom limb pain and improves limb use by altering brain connectivity. Early cortical changes, including shifts in hemispheric dominance, are observed shortly after TMR, supporting its effectiveness.

Keywords:
amputationfunctional connectivityfunctional near infrared spectroscopyhemispheric dominancehemodynamic responseneural plasticityphantom limb pain (PLP)targeted muscle reinnervation (TMR)

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