Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Principles of Disease Surveillance

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

Steps in Outbreak Investigation

Steps in Outbreak Investigation

In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:

Healthcare Associated Infections II: Preventive Measures

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

Infection

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

Introduction to Epidemiology

Introduction to Epidemiology

Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...

Strategies for Assessing and Addressing Confounding

Strategies for Assessing and Addressing Confounding

Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of improved water, sanitation, handwashing, and nutrition on early childhood IgG immune repertoire development against <i>Shigella</i> and enteroinvasive <i>Escherichia coli</i> (EIEC).

mSphere·2026

Same author

Animal husbandry and environmental conditions are associated with cefotaxime-resistant Escherichia coli in yard soil in peri-urban Malawi.

PLOS global public health·2026

Same author

Adaptive multi-model ensembles for improved epidemic projections and decision support.

medRxiv : the preprint server for health sciences·2026

Same author

Antimicrobial-resistant <i>E. coli</i> in human, animal and environmental reservoirs in rural Bangladeshi households with young children.

medRxiv : the preprint server for health sciences·2026

Same author

Unified framework for the ingestion of early epidemic data for downstream data analytics.

Wellcome open research·2026

Same author

Mapping the local effectiveness of mass drug administration for malaria using transportability methods.

Nature health·2026

Search research articles

Related Experiment Video

Updated: Jan 10, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

A framework for guiding integrated disease control measures through multipathogen surveillance.

Samantha J Bents, Francois Rerolle, Pearl Anne Ante-Testard

Medrxiv : the Preprint Server for Health Sciences

|November 24, 2025

Summary

Integrated disease control strategies using Rao's quadratic index can improve efficiency. This method quantizes multipathogen burden, guiding more effective interventions for infectious diseases in resource-limited settings.

More Related Videos

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Related Experiment Videos

Last Updated: Jan 10, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Area of Science:

Global Health
Epidemiology
Public Health Interventions

Background:

Traditional global health programs often target single diseases, potentially missing opportunities for synergistic intervention delivery.
Integrated approaches are promising for overlapping disease burdens, but methodologies for assessing efficiency gains are limited.

Purpose of the Study:

To apply Rao's quadratic index, a diversity measure, to quantify multipathogen burden.
To assess the efficiency of integrated, multipathogen-targeted strategies versus single-pathogen approaches for disease control.

Main Methods:

Utilized Rao's quadratic index to analyze multipathogen burden in large-scale surveys in Bangladesh and Cambodia.
Calculated the reduction in spatial clusters needed to achieve 75% disease burden coverage for integrated versus single-disease strategies.

Main Results:

Observed geographic clustering of multiple pathogens in both Bangladesh and Cambodia, indicating potential for integrated control.
Integrated deworming and measles vaccination in Bangladesh showed efficiency gains of 15-38%.
In Cambodia, Rao-guided strategies significantly reduced targeted spatial clusters for lymphatic filariasis (57%), Plasmodium falciparum (83%), and P. vivax (59%).

Conclusions:

Rao's quadratic index effectively quantifies multipathogen burden and geographic clustering.
Integrated disease control strategies guided by multipathogen burden metrics offer greater efficiency and may better reach under-resourced populations.
Findings support using multipathogen burden metrics to optimize integrated program delivery for enhanced disease control.