Risk Factors for Tumor Recurrence in Meningiomas: Multicenter Multivariate Analysis

Area of Science:

• Neurosurgery
• Oncology
• Radiology

Background:

• Meningiomas are common primary brain tumors.
• Understanding recurrence factors is crucial for patient management after surgery.

Purpose of the Study:

• To identify risk factors associated with imaging recurrence of meningiomas.
• To analyze the impact of clinical and surgical factors on tumor recurrence-free survival.

Main Methods:

• Retrospective analysis of 190 patients undergoing meningioma resection (2009-2019).
• Univariate and multivariate analyses for risk factors.
• Linear regression and mean comparison analyses for survival impact.

Main Results:

• Overall recurrence rate was 38.9% (74 patients).
• Intracranial hypertension syndrome was linked to higher recurrence risk.
• Greater intraoperative bleeding correlated with reduced recurrence-free survival.
• Petroclival location also reduced recurrence-free survival.

Conclusions:

• Intracranial hypertension syndrome may increase meningioma recurrence risk up to eightfold.
• Minimizing intraoperative bleeding is vital for improving outcomes.
• Clinical presentation and tumor location are significant factors in meningioma recurrence.