Related Experiment Video

Updated: Jan 10, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

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miRNA and Its Implications in the Treatment Resistance in Breast Cancer-Narrative Review of What Do We Know So Far

Isabela Anda Komporaly1,2, Adelina Silvana Gheorghe3, Lidia Anca Kajanto1,3

  • 1Department of Oncology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Non-Coding RNA
|November 24, 2025
PubMed

Insights

MicroRNAs (miRNAs) are key in breast cancer, affecting treatment resistance and progression. Research shows specific miRNAs can serve as biomarkers and potentially guide personalized oncology treatments for better patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a major global health concern, with treatment resistance and tumor heterogeneity presenting significant clinical hurdles.
  • MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, play crucial roles in breast cancer initiation, progression, and therapy resistance.

Purpose of the Study:

  • To review current evidence on the role of miRNAs in different breast cancer subtypes.
  • To explore the impact of miRNAs on treatment response and their potential as therapeutic targets or biomarkers.

Main Methods:

  • This study is a narrative review synthesizing recent scientific literature.
  • It focuses on the involvement of specific miRNAs (e.g., miR-155, miR-503, miR-21) and exosomal miRNAs in breast cancer.

Main Results:

  • Specific miRNAs show potential as non-invasive biomarkers and modulators of key signaling pathways (PI3K-Akt, MAPK, TNF).
  • Exosomal miRNAs may indicate chemoresistance and predict response to neoadjuvant therapy.
  • miRNAs are being investigated for sensitizing tumors to radiotherapy and modulating immune checkpoints (e.g., PD-L1) in triple-negative breast cancer.

Conclusions:

  • miRNAs hold promise for personalized breast cancer treatment, serving as biomarkers and therapeutic targets.
  • Further research is needed to standardize methodologies and validate miRNA signatures for clinical application in precision oncology.
Keywords:
biomarkersbreast cancermicroRNAs (miRNAs)molecular subtypesnon-coding RNA biomarkersprecision oncologytreatment resistancetumor heterogeneity

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