Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pattern of blast injuries. A systematic review: Part 2 - Landmines, unexploded ordnance and terrorism.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same author

Thermal Damage to the Skin From 5.6 GHz Microwave Exposures in Swine.

Bioelectromagnetics·2026
Same author

Evaluation of Emerging Technologies to Aid in the Detection and Diagnosis of Acute Extremity Compartment Syndrome.

Diagnostics (Basel, Switzerland)·2025
Same author

Modeling Sepsis: Establishment and Validation of a 72-Hour Swine Model of Penetrating Abdominal Trauma.

Medicina (Kaunas, Lithuania)·2025
Same author

Researcher's guide to preclinical animal models of acute extremity compartment syndrome.

Trauma surgery & acute care open·2025
Same author

Observational Analysis of Point-of-Care Lactate Plus™ Meter in Preclinical Trauma Models.

Diagnostics (Basel, Switzerland)·2024

Related Experiment Video

Updated: Jun 20, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

10.1K

Polymicrobial Infection (Gram-Positive and Gram-Negative) Exacerbates Systemic Inflammatory Response Syndrome in a

Catharina C Gaeth1, Travis R Madaris1, Jamila M Duarte1

  • 1Combat Wound Care, United States Army Institute of Surgical Research, 3698 Chambers Pass, Fort Sam Houston, TX 78234-6315, USA.

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|November 24, 2025
PubMed
Summary

Researchers developed a new swine model for complex extremity trauma that induces systemic inflammatory response syndrome (SIRS). This reproducible model aids in studying prolonged care and evaluating new trauma treatments.

Keywords:
SIRSextremity traumapreclinical trauma modelsprolonged casualty care

More Related Videos

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
07:16

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Published on: June 16, 2023

2.4K
Author Spotlight: Induction of Experimental Endotoxemic Shock in Pigs for Studying Hemodynamic and Respiratory Failure
05:52

Author Spotlight: Induction of Experimental Endotoxemic Shock in Pigs for Studying Hemodynamic and Respiratory Failure

Published on: December 8, 2023

1.4K

Related Experiment Videos

Last Updated: Jun 20, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

10.1K
Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation
07:16

Author Spotlight: Studying Host-Microbe Interactions in Wound Biofilm Formation

Published on: June 16, 2023

2.4K
Author Spotlight: Induction of Experimental Endotoxemic Shock in Pigs for Studying Hemodynamic and Respiratory Failure
05:52

Author Spotlight: Induction of Experimental Endotoxemic Shock in Pigs for Studying Hemodynamic and Respiratory Failure

Published on: December 8, 2023

1.4K

Area of Science:

  • Trauma research
  • Surgical innovation
  • Inflammatory response studies

Background:

  • Extremity trauma is common in battlefield and accident injuries.
  • Delayed treatment increases infection risk and mortality.
  • A need exists for better preclinical models of complex trauma.

Purpose of the Study:

  • To develop a conscious swine model of complex extremity trauma.
  • To induce systemic inflammatory response syndrome (SIRS) in the model.
  • To create a platform for evaluating trauma interventions.

Main Methods:

  • Created a complex extremity injury in swine (skin/muscle loss, bone defect, hemorrhage, tourniquet).
  • Inoculated injury site with multi-drug resistant bacteria (Gram-positive and Gram-negative).
  • Monitored animals for SIRS, pain, neurological response, and vital signs; collected blood samples.

Main Results:

  • Successfully developed a swine model of complex extremity trauma inducing SIRS.
  • Phase 1 showed SIRS maintained for up to 4 hours post-recovery.
  • Phase 2 demonstrated bacterial inoculation exacerbated and prolonged SIRS, with localized infection observed in all animals within 72 hours.

Conclusions:

  • Established a novel, reproducible swine model for complex extremity trauma and SIRS.
  • The model is suitable for prolonged care research.
  • Provides a foundation for testing preventative and therapeutic strategies for trauma injuries.