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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Related Experiment Video

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Murine Full-thickness Skin Transplantation
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Asymmetric Lip Hyperpigmentation in a Transplant Patient.

Vincent Kimpe1, David Alvarez Martinez1, Sébastien Menzinger1,2

  • 1Department of Dermatology and Venereology, University Hospital of Geneva, 1205 Geneva, Switzerland.

Dermatopathology (Basel, Switzerland)
|November 24, 2025
PubMed
Summary

Hyaluronic acid (HA) lip fillers may cause asymmetric hyperpigmentation in transplant patients on immunosuppression. Histology confirmed HA deposits and epidermal melanosis, ruling out other causes.

Area of Science:

  • Dermatology
  • Transplant Immunology
  • Aesthetic Medicine

Background:

  • Asymmetric hyperpigmentation of the lower lip can be concerning.
Keywords:
dermatopathologydrug-induced hyperpigmentationhyaluronic acid fillerpost-inflammatory hyperpigmentation

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  • Hyaluronic acid (HA) fillers are commonly used in aesthetic procedures.
  • Patients with organ transplants often require chronic immunosuppression.