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Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

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The Dynamic Change in the Neutrophil-Lymphocyte Ratio and Systemic Inflammatory Response Index After Undergoing an

Timothy P Dougherty^1,2, David J Carpenter³, Chris Peluso²

¹Department of Radiation Oncology, Allegheny Health Network, Pittsburgh, PA 15212, USA.

Journal of Functional Morphology and Kinesiology

|November 24, 2025

Summary

A 12-week intensive exercise program significantly reduced inflammatory markers, neutrophil-lymphocyte ratio (NLR) and systemic inflammatory response index (SIRI), in women with breast cancer. These findings suggest exercise may benefit breast cancer patients by improving inflammation.

Keywords:

body composition breast cancer exercise neutrophil–lymphocyte ratio quality of life resistance training survivorship systemic inflammatory response index

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Area of Science:

Oncology
Exercise Science
Immunology

Background:

Neutrophil-lymphocyte ratio (NLR) and systemic inflammatory response index (SIRI) are prognostic inflammatory markers in breast cancer.
Changes in these markers over time can indicate disease progression or treatment response.

Purpose of the Study:

To retrospectively evaluate the impact of a 12-week intensive resistance exercise program on NLR and SIRI in women with breast cancer.
To explore potential benefits of exercise interventions on systemic inflammation in breast cancer patients.

Main Methods:

Retrospective analysis of two prospective clinical trials (EXERT-BC, EXERT-BCN).
Analysis of complete blood count (CBC) values pre- and post-intervention in 21 eligible breast cancer patients.
Exclusion of participants undergoing active systemic therapy or with inflammatory conditions.

Main Results:

A 12-week intensive resistance exercise program led to a statistically significant reduction in both NLR and SIRI.
NLR decreased from 2.26 to 1.99 (p=0.016) and SIRI decreased from 1.23 to 0.80 (p=0.018).
Approximately two-thirds of participants experienced clinically relevant improvements in inflammatory markers.

Conclusions:

Intensive resistance exercise for 12 weeks is associated with improved NLR and SIRI in women with breast cancer.
While statistically significant, the small sample size and retrospective design limit generalizability.
Further prospective studies are warranted to validate exercise's role in modulating inflammation for breast cancer patients.