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Updated: Jan 10, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
False-positive [ 68 Ga]Ga-FAPI-04 PET/CT Following Treatment of 177 Lu-DOTATATE PRRT in a Patient With Metastatic
Rahul Vithalrao Parghane1,2, Subhash Yadav2,3, Austin Saju1,2
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe.
Abstract:
We present a high-grade well-differentiated NET with large lesions that demonstrated both SSTR and [ 18 F]F-FDG avidity on baseline PET/CT, an outstanding response following 177 Lu-DOTATATE-PRRT with complete resolution of SSTR and [ 18 F]F-FDG uptake, and significant size reduction of liver lesions. Non-SSTR and non-[ 18 F]F-FDG-avid change was noted in segment V, demonstrated uptake on [ 68 Ga]Ga-FAPI-04 PET/CT, and confirmed as fibrotic changes post-PRRT. Following PRRT, analysis of [ 68 Ga]Ga-FAPI-04 PET/CT in well-differentiated NET is important to avoid misinterpretation. Benign fibrosis following treatment may show FAPI uptake as a possible source of false-positive findings on [ 68 Ga]Ga-FAPI-04 PET/CT in the evaluation of NET.
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