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Development and psychometric validation of the Chronic Rhinosinusitis Control Test.

R A Cotter1, C W Lee1, K Wilson1

  • 1Department of Otolaryngology â€" Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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Summary

A new tool, the Chronic Rhinosinusitis Control Test (CRCT), effectively measures disease control in patients with chronic rhinosinusitis (CRS). This validated patient-reported outcome provides clear scoring to define controlled, partly controlled, and uncontrolled CRS.

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Area of Science:

  • Otolaryngology
  • Clinical Outcomes Research
  • Patient-Reported Outcome Measures

Background:

  • Assessing disease control in chronic rhinosinusitis (CRS) presents significant challenges.
  • A validated patient-reported outcome measure is needed for accurate CRS control assessment.

Purpose of the Study:

  • To develop and psychometrically validate the Chronic Rhinosinusitis Control Test (CRCT) for assessing CRS control.
  • To establish the validity, reliability, and responsiveness of the CRCT.

Main Methods:

  • The CRCT was developed incorporating stakeholder input and guidance from the COSMIN initiative and FDA.
  • Psychometric validation involved 545 CRS patients and 23 expert rhinologists, assessing validity, reliability, and responsiveness.
  • Factor analysis identified two subdomains: sinonasal and impairment, plus an item on oral corticosteroid use.

Main Results:

  • The CRCT demonstrated excellent face, content, concurrent validity, internal consistency, test-retest reliability, and responsiveness.
  • A minimal clinically important difference (MCID) of 4 points was established using distribution-based and anchor-based methods.
  • Expert rhinologists defined scoring criteria: ≤7 for controlled CRS, 8-15 for partly controlled, and ≥16 for uncontrolled CRS.

Conclusions:

  • The Chronic Rhinosinusitis Control Test (CRCT) is a psychometrically validated tool for assessing CRS control.
  • The CRCT provides clear thresholds for classifying CRS as controlled (≤7), partly controlled (8-15), or uncontrolled (≥16).
  • The MCID for both improvement and worsening of CRS is 4 points on the CRCT.