Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Glucose Availability Sensitizes Pancreatic Cancer to Macrophage-Targeting Immunotherapies.

Cancer research communications·2026
Same author

MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.

Genes & development·2026
Same author

Liquid Biopsy Differentiation of Pancreatic Cancer From Non-Cancerous Pancreatic Disease Using Dielectrophoresis-Recovered Nanoparticles Carrying Cell-Free DNA and Protein Biomarkers.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexia.

American journal of physiology. Cell physiology·2026
Same author

Development and Validation of a Computational Histology Artificial Intelligence-Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Global mRNA 3'UTR lengthening in small-cell neuroendocrine carcinoma.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 10, 2026

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
06:57

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models

Published on: April 7, 2018

11.4K

MicroCT Enables Simultaneous Longitudinal Tracking of Murine Pancreatic Cancer Progression and Cachexia.

Katherine R Pelz1,2,3, Philip Jimenez2, Colin J Daniel4

  • 1Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon.

Cancer Research Communications
|November 24, 2025
PubMed
Summary

A new dual-contrast microCT method allows noninvasive, longitudinal tracking of pancreatic cancer growth, metastasis, and muscle wasting in mice. This preclinical imaging platform aids in evaluating therapeutic responses and understanding disease progression.

More Related Videos

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window
06:52

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window

Published on: May 6, 2021

4.7K
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
06:24

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

15.6K

Related Experiment Videos

Last Updated: Jan 10, 2026

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
06:57

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models

Published on: April 7, 2018

11.4K
Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window
06:52

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window

Published on: May 6, 2021

4.7K
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
06:24

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

15.6K

Area of Science:

  • Biomedical Imaging
  • Preclinical Oncology
  • Translational Research

Background:

  • Noninvasive imaging is crucial for evaluating pancreatic ductal adenocarcinoma (PDAC) progression and treatment response in preclinical models.
  • Current imaging methods lack the ability to simultaneously track primary tumor growth, metastatic spread, and host cachexia over time.

Purpose of the Study:

  • To develop and optimize a dual-contrast microCT protocol for longitudinal, noninvasive imaging in orthotopic murine models of PDAC.
  • To enable simultaneous, high-resolution quantification of primary tumors, metastases, and skeletal muscle wasting.

Main Methods:

  • An optimized dual-contrast microCT protocol was implemented for longitudinal imaging in orthotopic murine PDAC models.
  • The method allowed for volumetric quantification of primary tumors, liver and lung metastases, and paraspinal skeletal muscle.
  • MicroCT measurements were compared with endpoint tumor weights and 2D ultrasound.

Main Results:

  • MicroCT measurements strongly correlated with endpoint tumor weights and showed superior accuracy over 2D ultrasound for early tumor detection.
  • The platform revealed heterogeneous metastatic kinetics and early onset of skeletal muscle wasting across different PDAC models.
  • MicroCT radiation dose did not impact model endpoints.

Conclusions:

  • Dual-contrast microCT provides a powerful, clinically relevant imaging platform for preclinical PDAC research and therapeutic testing.
  • This method enables dynamic, whole-body assessment of tumor progression and host physiological changes, mimicking clinical CT surveillance.
  • The protocol offers advantages over destructive endpoint analyses by capturing temporal dynamics of disease and host response.