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Related Concept Videos

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
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Related Experiment Video

Updated: Jan 6, 2026

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Neurological Events Associated With Acute Dengue Infection.

Liang En Wee1,2,3, Wei Zhi Tan1, Jo Yi Chow4

  • 1Communicable Diseases Agency, Singapore.

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Dengue virus (DENV) infection significantly increases the risk of acute neurological events, including memory loss and movement disorders, particularly in older adults. While the overall excess burden is modest, monitoring for these complications is crucial.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Epidemiology

Background:

  • Global incidence of dengue virus (DENV) infection is rising, necessitating better estimates of associated neurological complications.
  • Population-based data on the burden of neurological events post-DENV infection are limited.

Purpose of the Study:

  • To assess the risk and excess burden of neurological events in adults following DENV infection compared to uninfected individuals.
  • To identify specific neurological event types and risk factors associated with DENV infection.

Main Methods:

  • Retrospective, population-based cohort study in Singapore using national registries.
  • Compared 65,207 DENV-infected adults with 1,616,865 uninfected comparators from 2017-2023.
  • Neurological events identified via health care claims; risk analyzed 30-90 days post-infection.

Main Results:

  • DENV infection was associated with significantly higher odds of acute neurological events (aOR 9.69) within 30 days.
  • Elevated odds observed for memory loss (aOR 3.19), movement disorders (aOR 7.10), and other neurological events (aOR 14.32).
  • Increased risk for memory loss and movement disorders was notable in individuals aged ≥60 years and those infected with DENV serotype 3.

Conclusions:

  • DENV infection elevates the risk of acute neurological events, though the overall excess burden is modest.
  • Older adults (≥60 years) and those with DENV serotype 3 infection require closer monitoring for neurological complications.
  • Findings highlight the importance of recognizing and managing neurological sequelae of DENV infection.