Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

Overview
Bacterial Growth Curve01:28

Bacterial Growth Curve

The bacterial growth curve is a fundamental concept in microbiology that describes the dynamics of bacterial population growth in a closed system with controlled environmental conditions, such as temperature and nutrient availability. This curve is divided into four distinct phases: lag, log (exponential), stationary, and death phases, each reflecting a unique stage of bacterial adaptation and growth. During the lag phase, bacteria acclimate to their surroundings by synthesizing essential...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Hepatitis C Virus Antibody Testing Strategy and Setting: Results From a Large Real-World Screening Program.

Open forum infectious diseases·2026
Same author

European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Single-Use vs Reusable Catheters for Intermittent Catheterization in Patients With Urinary Retention: The COMPARE Randomized Clinical Trial.

JAMA network open·2026
Same author

Association of FUT2 rs601338 Genotype with Colonic Mucosal Microbiome Composition, Post-Transplant Bacteremia, and All-Cause Mortality After Liver Transplantation for Primary Sclerosing Cholangitis: A Retrospective Cohort Study.

Journal of clinical medicine·2026
Same author

Bezafibrate for primary biliary cholangitis: A number needed to treat analysis.

JHEP reports : innovation in hepatology·2026
Same author

A Nationwide Assessment of Anticholestatic Therapy Uptake in Patients With Primary Biliary Cholangitis: Opportunities for Optimisation.

Alimentary pharmacology & therapeutics·2026

Related Experiment Video

Updated: Jul 2, 2026

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
08:08

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy

Published on: October 16, 2013

10.9K

Condition-Specific Growth Charts for Children With Alagille Syndrome.

Koen Huysentruyt1,2, Shannon M Vandriel2, Mathieu Roelants3

  • 1Kindergastro-enterologie, hepatologie en nutritie, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

JAMA Network Open
|November 24, 2025
PubMed
Summary

New Alagille syndrome (ALGS) growth charts show significant differences from standard charts. These condition-specific tools can help clinicians better assess growth and guide liver transplant decisions for children with ALGS.

More Related Videos

Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

7.3K
Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering
09:43

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

Published on: November 22, 2019

6.7K

Related Experiment Videos

Last Updated: Jul 2, 2026

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
08:08

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy

Published on: October 16, 2013

10.9K
Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

7.3K
Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering
09:43

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

Published on: November 22, 2019

6.7K

Area of Science:

  • Pediatric Endocrinology
  • Genetics and Rare Diseases
  • Clinical Data Analysis

Background:

  • Children with Alagille syndrome (ALGS) exhibit variable growth delays.
  • Current evaluation relies on standard growth charts, which may not accurately reflect ALGS-specific growth patterns.
  • The need for specialized growth assessment tools in ALGS is critical for accurate monitoring and management.

Purpose of the Study:

  • To develop and validate condition-specific growth charts for children with Alagille syndrome.
  • To utilize modern statistical methods for creating accurate percentile plots for weight and height in ALGS patients.
  • To compare ALGS growth patterns with those represented by standard US Centers for Disease Control and Prevention (CDC) growth charts.

Main Methods:

  • Data from 1204 children with clinically or genetically confirmed ALGS were analyzed from the Global Alagille Alliance (GALA) study.
  • Generalized additive models for location scale and shape (GAMLSS) were employed to generate weight-for-age and height-for-age percentile charts.
  • The developed charts were superimposed on CDC growth charts to highlight discrepancies in growth trajectories.

Main Results:

  • Condition-specific growth charts for boys and girls with ALGS demonstrated significant differences compared to CDC charts.
  • At 18 years, the median height for ALGS boys was 171.5 cm (vs. 176 cm on CDC charts) and for ALGS girls was 156.5 cm (vs. 163 cm on CDC charts).
  • The study included a large cohort with detailed clinical data, including neonatal cholestasis and liver transplant history.

Conclusions:

  • The developed condition-specific growth charts for Alagille syndrome provide a vital clinical tool for accurate growth assessment.
  • These specialized charts can aid healthcare providers in making informed decisions regarding patient management and liver transplant evaluations.
  • Implementing ALGS-specific growth charts is crucial for improving the care and monitoring of affected children.