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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 10, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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An Eye Video Oriented and rPPG-Based Intraocular Pressure Detection Method.

Kun Zheng, Xuejia Zhen, Boxiang Hu

    IEEE Journal of Biomedical and Health Informatics
    |November 24, 2025
    PubMed
    Summary

    This study introduces a novel video-based method using remote photoplethysmography (rPPG) to detect and classify intraocular pressure (IOP). The IOP-Net model shows potential for convenient, non-contact IOP assessment.

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    Area of Science:

    • Ophthalmology
    • Biomedical Engineering
    • Computer Vision

    Background:

    • Current intraocular pressure (IOP) measurement relies on inconvenient contact methods.
    • There is a need for non-contact, accessible IOP monitoring solutions.
    • Ophthalmological diagnostics can benefit from advanced imaging techniques.

    Purpose of the Study:

    • To develop and validate a novel video-based method for detecting and classifying intraocular pressure (IOP).
    • To utilize remote photoplethysmography (rPPG) for non-contact IOP assessment.
    • To create an AI model capable of distinguishing between normal and high IOP from eye videos.

    Main Methods:

    • Developed the IOP-Net model, a convolutional neural network (CNN) with four layers.
    • Extracted blood volume pulse (BVP) signals from key regions of interest (ROIs) in eye videos: pupil, iris, and sclera.
    • Trained the CNN model using extracted BVP signals for IOP detection and classification.

    Main Results:

    • The IOP-Net model achieved root mean square errors (RMSE) of 3.14 mmHg on the EVIP-1 dataset and 4.19 mmHg on the EVIP-2 dataset.
    • Demonstrated an accuracy of 80.25% in classifying high IOP when the ground truth IOP exceeded 30 mmHg.
    • Successfully detected and classified IOP using video-based rPPG signals.

    Conclusions:

    • The proposed video-based rPPG method offers a promising and potential approach for non-contact IOP detection and classification.
    • IOP-Net demonstrates feasibility for widespread application in remote IOP monitoring.
    • This innovative technique could enhance the convenience and accessibility of IOP assessment.