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Alendronate-Based Polypeptide Hydrogels with Osteogenic Potential for Digital Light Processing.

Muireann Cosgrave1, Avelino Ferreira2, Ciara M Murphy2,3,4

  • 1Department of Chemistry, RCSI University of Medicine and Health Science, Dublin 2 D02 YN77, Ireland.

ACS Applied Materials & Interfaces
|November 24, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces an alendronate star polypeptide hydrogel for 3D bone tissue engineering. The formulation enhances mechanical properties and promotes cell growth for potential bone regeneration applications.

Keywords:
3D printingcalcium cross-linkinghydrogelsosteogenic potentialpolypeptides

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biotechnology

Background:

  • Hydrogels are widely used in tissue engineering due to their biocompatibility.
  • Developing hydrogels with enhanced mechanical properties and osteoconductive potential remains a challenge.
  • Alendronate, a bisphosphonate, has high affinity for calcium ions and can influence mineralization.

Purpose of the Study:

  • To develop a novel alendronate star polypeptide hydrogel formulation.
  • To investigate the impact of alendronate incorporation on hydrogel properties and bone regeneration.
  • To assess the potential of the hydrogel for digital light processing 3D printing.

Main Methods:

  • Fabrication of alendronate star polypeptide hydrogels using digital light processing.
  • Characterization of hydrogel mechanical properties (e.g., Young's modulus).
  • In vitro studies using rat mesenchymal stem cells (rMSCs) to evaluate osteogenesis and mineralization.

Main Results:

  • Successful high-resolution 3D printing of hydrogel structures.
  • Significant enhancement in hydrogel mechanical properties, approaching native bone values.
  • Demonstrated Ca2+ mediated mineralization and fostered osteogenesis in seeded rMSCs.

Conclusions:

  • Alendronate star polypeptide hydrogels offer improved mechanical strength and osteoconductivity.
  • The formulation shows promise for bone tissue regeneration applications.
  • Digital light processing enables precise fabrication of these advanced biomaterials.