Related Experiment Video
Updated: Jan 10, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
MICROSCOPE-INTEGRATED INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY FOR INTRAOCULAR LENS TILT EVALUATION DURING
Sigeng Lin1,2, Kaicheng Wu1,2, Jiemei Shi1,2
1Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China.
Purpose:
The aim of this study was to evaluate the feasibility and clinical utility of a commercially available microscope-integrated intraoperative optical coherence tomography (MI-OCT) system during scleral-sutured fixation of intraocular lenses (IOLs).
Methods:
Scleral-sutured IOL fixation was performed in 18 eyes using the Zeiss Rescan 700 MI-OCT system. Intraoperative optical coherence tomography images were captured, and the utility of MI-OCT in the procedure was assessed.
Results:
Eighteen eyes from 18 patients underwent scleral-sutured IOL fixation using the MI-OCT system. The system provided clear anterior segment images in all cases. In 15 cases, the captured images provided crucial information for evaluating IOL tilt in at least one meridian (0° or 90°). In the remaining cases, failure to assess tilt was attributed to iris asymmetry (2 cases) or a very posteriorly positioned IOL (1 case) in both horizontal and vertical meridians. In 16 cases with at least 3 months of follow-up, spherical equivalent significantly improved (preoperative: +5.72 ± 6.97 D; postoperative: -1.57 ± 1.77 D; P = 0.004), while corneal endothelial cell density, best-corrected visual acuity, and intraocular pressure remained stable. Postoperative Pentacam HR imaging demonstrated a mean IOL tilt of 0.98 ± 0.93° horizontally and 1.67 ± 1.37° vertically.
Conclusion:
The commercial MI-OCT system enabled intraoperative evaluation of IOL tilt during scleral-sutured IOL fixation, although its utility was limited in cases involving asymmetric iris or posteriorly located IOLs. Future systems with wider and deeper scanning ranges and the ability to reference the anterior chamber angle may enhance performance.
More Related Videos
12:22Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
Published on: August 4, 2018
06:55Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses
Published on: June 6, 2017