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Rescaling pMBRT plans for uniform target dose.

Fardous Reaz1,2, Niels Bassler1,2

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Summary
This summary is machine-generated.

A new method improves proton minibeam radiation therapy (pMBRT) dose uniformity. Combined transverse and longitudinal rescaling of spot weights ensures homogeneous target dose delivery, enhancing treatment efficacy and simplifying comparisons with conventional radiotherapy.

Keywords:
SFRToptimizationpMBRT

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Particle Therapy

Background:

  • Proton minibeam radiation therapy (pMBRT) offers improved tumor control and reduced healthy tissue damage.
  • Mechanical collimators are used in pMBRT for dose shaping but introduce dose inhomogeneities.
  • Uniform dose delivery is crucial for pMBRT evaluation and comparison with conventional radiotherapy.

Purpose of the Study:

  • To develop and validate a combined transverse and longitudinal rescaling method to enhance dose uniformity in pMBRT.
  • To address dose inhomogeneities caused by mechanical collimators in pMBRT.
  • To achieve clinically acceptable dose uniformity within the planning target volume.

Main Methods:

  • Utilized Geant4 Monte Carlo simulations to quantify dose profiles for various energy layers.
  • Developed a rescaling algorithm adjusting spot weights based on proton energy and lateral position.
  • Applied combined transverse and longitudinal rescaling factors to correct collimator-induced dose inhomogeneities.

Main Results:

  • Individual transverse or longitudinal rescaling alone did not meet clinical standards for dose uniformity.
  • The combined rescaling method achieved a uniform dose distribution within the planning target volume.
  • The final dose distribution was within the clinically acceptable range of 95%-107%.

Conclusions:

  • Combined transverse and longitudinal rescaling is essential for achieving uniform dose coverage in pMBRT.
  • The developed method significantly improves dose homogeneity in pMBRT.
  • Optimized pMBRT dose uniformity facilitates clinical evaluation and comparison.