Related Experiment Video
Updated: Jan 10, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Association between genomic single nucleotide polymorphisms and susceptibility of Talaromyces marneffei
Xiaofeng Li1, Wenran Dan1, Ming Luo1
1Clinical Laboratory, Chongqing Public Health Medical Center, Chongqing, China.
Abstract:
Talaromyces marneffei is a pathogenic fungus that causes talaromycosis. Although many antifungal drugs have been used for the treatment of talaromycosis, the effects of genomic mutations in different T. marneffei strains on the susceptibility to these antifungal drugs have not been fully studied. To reveal the association between genomic single nucleotide polymorphisms (SNPs) and susceptibility to T. marneffei, we sequenced the genomes of 15 clinical isolates of T. marneffei and analyzed the association between their SNPs and susceptibilities to 5-fluorouracil, anidulafungin, posaconazole, voriconazole, fluconazole, caspofungin, amphotericin B, micafungin, and itraconazole. A total of 87.29 Gb of sequencing reads were obtained from the 15 isolates, and 90,131 SNP loci were detected when compared to the reference genome of T. marneffei. Nine, one, one, and 14 SNP loci were potentially correlated with fluconazole, micafungin, posaconazole, and caspofungin susceptibilities, respectively. These results provide valuable genomic data for further analysis of drug resistance mechanisms and treatment strategies.
More Related Videos
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs
Modern Molecular Taxonomy
Incomplete Dominance

