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Related Experiment Video

Updated: Jan 10, 2026

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
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Reorganized Functional Networks Underlie Working Memory Deficits After Right-Hemispheric Stroke.

Emilie Marti1, Sélim Yahia Coll1, Naz Doganci1

  • 1Research Group Spatial Attention, Perception and Action, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

The European Journal of Neuroscience
|November 24, 2025
PubMed
Summary
This summary is machine-generated.

Stroke patients show impaired working memory (WM) due to disrupted brain network connectivity. Reduced connectivity within the right hemisphere (RH) brain regions correlated with poorer WM, while increased connectivity between hemispheres suggested compensation.

Keywords:
frontoparietal networkfunctional connectivityresting‐state fMRIstrokeworking memory

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Working memory (WM) is crucial for cognition, but stroke often impairs it.
  • Traditional lesion mapping misses large-scale brain network changes impacting WM post-stroke.

Purpose of the Study:

  • Investigate working memory (WM) deficits in right hemisphere (RH) stroke patients using functional connectivity (FC) analysis.
  • Examine the relationship between frontoparietal network FC and WM performance in RH stroke survivors.

Main Methods:

  • Utilized resting-state fMRI for seed-to-voxel FC analysis in 34 RH stroke patients and 35 controls.
  • Assessed WM performance using verbal and spatial N-back tasks.
  • Correlated FC measures with WM task accuracy.

Main Results:

  • Stroke patients displayed altered FC-WM associations compared to controls.
  • Reduced intrahemispheric FC in RH correlated with lower WM performance.
  • Enhanced interhemispheric FC showed a positive association with WM accuracy, indicating compensatory mechanisms.

Conclusions:

  • Working memory deficits post-stroke result from altered brain network dynamics, not just focal damage.
  • Reduced intrahemispheric connectivity may be compensated by interhemispheric recruitment.
  • Findings emphasize early network reorganization's role in cognitive recovery after stroke.