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Tuning Molecular Interactions between Peptoids and Substrates to Achieve Surface-Agnostic Coating.

Wenhao Zhou1,2, Botao Hao1, Thi Kim Hoang Trinh1

  • 1Physical Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99354, United States.

ACS Applied Materials & Interfaces
|November 24, 2025
PubMed
Summary

Researchers developed adaptable and stable surface-agnostic coatings (SACs) using crystalline peptoid membranes. These programmable coatings offer tunable properties and adhere to diverse surfaces, advancing functional interface design.

Keywords:
biomimetic polymersmoisture vapor transportpeptoid membranesself-assemblysubstrate interactionssurface-agnostic coating

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Area of Science:

  • Materials Science
  • Surface Chemistry
  • Nanotechnology

Background:

  • Developing robust, functional coatings adaptable to various surfaces is a significant challenge.
  • Molecular-level control over coating properties and adhesion remains difficult to achieve.

Purpose of the Study:

  • To engineer adaptable and stable surface-agnostic coatings (SACs) with programmable features.
  • To explore the use of crystalline peptoid membranes for tunable surface modification.

Main Methods:

  • Utilized surface-induced assembly and aqueous layer-by-layer (LbL) assembly to form peptoid membranes.
  • Applied these methods to diverse substrates including mica, HOPG, MoS2, sapphire, and porous membranes.
  • Characterized coating formation using atomic force microscopy (AFM) and assessed membrane properties via moisture vapor transport measurements.

Main Results:

  • Successfully formed peptoid coatings on substrates with varied chemistries and topographies.
  • Observed distinct assembly behaviors across different surfaces.
  • Demonstrated tunable permeance of the peptoid membranes, confirming their continuity and functionality.

Conclusions:

  • Peptoid-based SACs exhibit remarkable adaptability and programmability for rational coating design.
  • These findings enable the development of advanced functional interfaces, protective coatings, and membrane platforms.
  • This work presents a novel approach for surface modification using crystalline peptoid membranes.