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Early aminophylline is a potential therapy for preventing bronchopulmonary dysplasia in premature infants: a

Lijun Tang1, Qiqiong Wang1, Linmei Jiang1

  • 1Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

BMC Pediatrics
|November 25, 2025
PubMed

Insights

Early aminophylline use in premature infants may reduce bronchopulmonary dysplasia (BPD) incidence. This study found no significant adverse reactions, suggesting a potential safety benefit for early intervention in preterm infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Pharmacology

Background:

  • Aminophylline is a common treatment for apnea in premature infants.
  • Long-term effects of aminophylline on preterm infant complications remain unclear.
  • This study investigates the impact of early aminophylline administration.

Purpose of the Study:

  • To evaluate the effects of early aminophylline use in premature infants.
  • To assess the safety profile of early aminophylline administration.
  • To determine if early intervention impacts long-term complications like BPD.

Main Methods:

  • Retrospective study of 296 premature infants (gestational age < 32 weeks, weight < 1500 g).
  • Infants received either early or late aminophylline treatment.
  • Clinical data on outcomes and adverse reactions were collected and analyzed.

Main Results:

  • The early aminophylline group (208 infants) showed a significantly lower incidence of bronchopulmonary dysplasia (BPD) compared to the late group (88 infants).
  • Subgroup analysis by gestational age revealed shorter durations of mechanical ventilation and oxygen therapy in infants receiving early aminophylline.
  • No significant differences in adverse reactions were observed between the early and late treatment groups.

Conclusions:

  • Early aminophylline use in premature infants is associated with a reduced incidence of BPD.
  • The findings suggest a potential benefit of early intervention without increased adverse events.
  • Further research may confirm the long-term benefits of early aminophylline for preterm infants.
Abstract

Keywords:
AminophyllineBronchopulmonary dysplasiaMechanical ventilationNon-invasive ventilationVery premature infants

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