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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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Cancer-Associated Thrombosis (CAT); mechanisms and treatment options
Fahad S Alshehri1,2, Abdurahman Alloghbi3, Abdulrahman Alshalani4
1King Faisal Medical City for Southern Region, Pathology and Clinical Laboratory Medicine Department, Haematology Division, Abha, Saudi Arabia. fsalshehrii@kfmcity.med.sa.
Thrombosis Journal
|November 25, 2025
Summary
Cancer-associated thrombosis (CAT) is a major cause of death in cancer patients. This review explores the link between cancer and thrombosis, including risk factors and molecular mechanisms.
Area of Science:
- Oncology
- Hematology
- Vascular Biology
Background:
- Cancer-associated thrombosis (CAT) is a significant cause of mortality in cancer patients, second only to cancer itself.
- Cancer is the leading cause of death among patients experiencing thrombosis, underscoring the critical link between these conditions.
- Tumor cells actively create a prothrombotic state by activating host cell procoagulant properties.
Purpose of the Study:
- To review the association between cancer and thrombosis.
- To outline common risk factors for cancer-associated thrombosis.
- To discuss the molecular mechanisms underlying cancer and thrombosis.
Main Methods:
- Literature review of studies on cancer-associated thrombosis.
- Analysis of risk factors including cancer type and treatments.
- Examination of molecular pathways involved in thrombosis in cancer patients.
Main Results:
- Cancer patients have a significantly higher prevalence of both arterial thromboses (myocardial infarction, ischemic stroke) and venous thromboses (deep vein thrombosis, pulmonary embolism).
- Chemotherapy, radiotherapy, and hormone treatments can exacerbate the risk of thrombosis in cancer patients.
- Tumor cells directly contribute to a prothrombotic state.
Conclusions:
- There is a strong, multifaceted relationship between cancer and thrombosis.
- Understanding the risk factors and molecular mechanisms is crucial for managing CAT.
- Further research into molecular mechanisms may lead to improved prevention and treatment strategies.
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