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Updated: Jan 6, 2026
All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
Published on: December 20, 2021
A Pan-Cancer Analysis of the Oncogenic Role of YES Proto-Oncogene 1 (YES1) in Human Tumors
Ruohan Dou1, Ling Han2, Guanya Liu3,4
1Department of Anesthesiology, Huadong Hospital, Fudan University, Shanghai, China.
Background:
Numerous studies have underscored the oncogenic function of YES Proto-Oncogene 1 (YES1) in various tumors. However, the relationship between YES1 and different tumors in pan-cancer patients, based on extensive clinical data, remains unclear.
Methods:
Integrating data from bioinformatics platforms (TIMER2, GEPIA2, UALCAN, cBioPortal, UniProt, STRING, and DAVID), we systematically interrogated YES1 expression patterns across malignancies. Multidimensional assessments encompassing clinical outcomes, genetic alteration profiles, post-translational modifications, and immunocyte infiltration dynamics were performed. Pathway enrichment mapping was subsequently applied to delineate oncogenic signaling networks.
Results:
Tumor-type-specific YES1 expression signatures demonstrated significant prognostic stratification capacity. Molecular profiling revealed some core pathological mechanisms: genomic instability hotspots, phosphoproteomic deregulation in malignancies, and CAF-dominated tumor microenvironment remodeling in mesenchymal neoplasms. Systems biology approaches further uncovered YES1-mediated coordination of hallmark cancer processes, particularly cancer-related signaling pathways and protein processing functions.
Conclusion:
This initial systematic pan-cancer investigation establishes YES1 as a pleiotropic oncogenic regulator, with mechanistic heterogeneity across tumor lineages. The multidimensional characterization provides a translational framework for developing lineage-specific therapeutic strategies targeting YES1 signaling networks.
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