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Otologic Diagnoses Among Patients With Adult-onset and Pediatric-onset Antiphospholipid Syndrome: A Database Study

Tejal Patki1, Aashish Batheja1, Beth Rubinstein2

  • 1Department of Otolaryngology/Head and Neck Surgery, Virginia Commonwealth University School of Medicine.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|November 25, 2025
PubMed

Insights

Antiphospholipid syndrome (APS) is linked to increased otologic conditions like hearing loss and vertigo in both adults and children. Further research is needed to understand these associations.

Area of Science:

  • Otolaryngology
  • Rheumatology
  • Genetics

Background:

  • Antiphospholipid syndrome (APS) is an autoimmune disorder associated with an increased risk of thrombosis and pregnancy complications.
  • The otologic manifestations of APS are not well-characterized, particularly in pediatric populations.

Purpose of the Study:

  • To investigate the prevalence of otologic diagnoses in adult-onset and pediatric-onset APS.
  • To compare the risk of specific otologic conditions in APS patients versus the general population.

Main Methods:

  • Retrospective cohort study using the TriNetX US Collaborative network.
  • Adult and pediatric APS cohorts were compared with matched general population cohorts.
  • Outcomes included sensorineural hearing loss (SNHL), vertigo (central and peripheral), tinnitus, and Ménière's disease.

Main Results:

  • Adult APS patients showed higher risks for SNHL, central and peripheral vertigo, tinnitus, and Ménière's disease.
  • Pediatric APS patients had a significantly higher risk of bilateral SNHL.
  • Relative risks (RR) and 95% confidence intervals (CI) were calculated for each condition.

Conclusions:

  • Both adult and pediatric APS are associated with a greater prevalence of various otologic diagnoses compared to the general population.
  • Further research is warranted to identify patient-specific factors contributing to these otologic conditions in APS.
Abstract

Keywords:
Antiphospholipid syndromeAutoimmune diseaseHearing LossTinnitusVertigo

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