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Published on: November 21, 2025
245
Pyroptosis-induced tissue damage in kidney disease
Zhiyuan Zhang1, Xiaodi Li1, Yang Han2
1Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Renal Failure
|November 25, 2025
Summary
Pyroptosis, a programmed cell death, drives kidney damage and end-stage renal disease by causing inflammation. Targeting pyroptosis offers a potential strategy to reduce irreversible renal injury and improve patient prognosis.
Area of Science:
- Cell Biology
- Immunology
- Pathology
Background:
- Pyroptosis is a pro-inflammatory programmed cell death pathway mediated by gasdermin proteins.
- It plays a dual role in host defense and disease pathogenesis, including autoimmune disorders and cancer.
- Dysregulated pyroptosis contributes to chronic inflammation and tissue damage in kidney, cardiovascular, and metabolic disorders.
Purpose of the Study:
- To detail pyroptosis signaling pathways.
- To focus on mechanisms of pyroptosis-induced renal tissue damage.
- To review new therapeutic advances targeting pyroptosis in kidney disease.
Main Methods:
- Literature review of pyroptosis mechanisms and renal pathology.
- Analysis of signaling pathways involved in pyroptosis.
- Synthesis of current research on pyroptosis-targeted therapies for kidney diseases.
Main Results:
- Pyroptosis is implicated in irreversible renal tissue damage and progression to end-stage renal disease.
- Inflammatory responses in kidney diseases, particularly acute kidney injury, are linked to pyroptosis.
- Targeting pyroptosis presents a promising therapeutic avenue for mitigating renal damage.
Conclusions:
- Pyroptosis is a critical factor in kidney disease progression and prognosis.
- Understanding pyroptosis pathways is essential for developing effective treatments.
- Targeting pyroptosis holds potential for alleviating irreversible renal damage and improving outcomes in kidney disease patients.
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