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A 3D Spheroid Model for Glioblastoma
Published on: April 9, 2020
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3D bioprinted glioma models
Defne Yigci1, Misagh Rezapour Sarabi2, Merve Ustun2
1School of Medicine, Koc University, 34450 Istanbul, Turkey.
Progress in Biomedical Engineering (Bristol, England)
|November 25, 2025
Summary
3D bioprinting creates advanced in vitro models to study glioma invasion and drug resistance. This technology offers a cost-effective way to mimic the brain tumor microenvironment for personalized treatments.
Area of Science:
- Biomedical Engineering
- Cancer Research
- Neuro-oncology
Background:
- Glioma is a highly invasive and often incurable brain cancer.
- Glioma cell invasiveness complicates surgical resection and treatment.
- Current models struggle to fully replicate the complex tumor microenvironment.
Purpose of the Study:
- To review 3D bioprinted models for studying glioma.
- To explore their utility in probing glioma cell invasion and drug resistance.
- To discuss future applications of 4D printing and machine learning in glioma modeling.
Main Methods:
- Review of emerging 3D bioprinting technologies for creating in vitro glioma models.
- Focus on biomimetic scaffold-free cultures, organ-on-chip systems, and bioprinted platforms.
- Discussion of patient-specific modeling capabilities.
Main Results:
- 3D bioprinting enables the creation of in vitro models with structural and functional tissue characteristics.
- These models can recapitulate the brain environment and glioma tumors.
- 3D bioprinting offers a time- and cost-efficient approach for advanced research.
Conclusions:
- 3D bioprinting is a promising technology for developing sophisticated in vitro glioma models.
- These models can advance understanding of glioma invasion, drug resistance, and gliomagenesis.
- Future integration with 4D printing and machine learning holds significant potential for personalized glioma treatment strategies.
