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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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Immune Checkpoint Inhibitor-Induced Central and Peripheral Neurotoxicity: Case Series and Literature Review

Shuvangee Dhar1, Naresh Mullaguri2,3,4, Sanjeev Sivakumar5

  • 1Neurology, Prisma Health-Upstate/University of South Carolina School of Medicine Greenville, Greenville, USA.

Cureus
|November 25, 2025
PubMed
Summary

Immune checkpoint inhibitors (ICIs) offer cancer treatment benefits but can cause neurological immune-related adverse events (irAEs). Managing these neurotoxicities requires careful consideration of ICI discontinuation and rechallenging risks.

Keywords:
central neurotoxicityencephalitisimmune-checkpoint inhibitormyasthenia gravisperipheral neurotoxicity

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