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Factors Associated With Systemic Corticosteroid Use in Patients With Asthma: A Real-Life Study.

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Systemic corticosteroid (SCS) overuse in Mexican asthma patients is linked to severe disease, eosinophilic inflammation, and nasal polyposis. Reducing reliance on SCS is crucial for minimizing adverse effects and improving asthma management.

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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Pharmacology

Background:

  • Asthma is a chronic respiratory disease with significant global impact.
  • Systemic corticosteroids (SCS) are used for severe asthma but carry risks.
  • Limited data exists on SCS use patterns in Mexican asthma patients.

Purpose of the Study:

  • To identify factors associated with systemic corticosteroid (SCS) use in Mexican asthma patients.
  • To investigate the relationship between SCS use and asthma severity, endotype, comorbidities, and diagnosis duration.
  • To inform strategies for reducing SCS overuse and associated adverse events.

Main Methods:

  • A multicenter ambispective study involving 152 asthma patients in Mexico.
  • Data collection included clinical and laboratory information on SCS use, asthma characteristics, and comorbidities.
  • Statistical analysis employed descriptive and inferential methods.

Main Results:

  • Nearly half (48.7%) of patients used SCS in the past 12 months.
  • SCS use was significantly higher in severe asthma (81.8%), eosinophilic endotype (83.3%), and those with nasal polyposis (100%).
  • Higher median eosinophil counts (208 vs. 114) were observed in SCS users.

Conclusions:

  • Disease severity, eosinophilic inflammation, and nasal polyposis are key factors associated with SCS use in asthma.
  • Findings underscore the need for targeted therapies like biologics to decrease SCS dependency.
  • Optimizing early diagnosis and asthma management is vital for better outcomes and reduced long-term risks.