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Hyperuricemia Is Independently Associated With Hyperlipidemia in a Large Population-Based Study
Ta-Jen Lin1, Jia-In Lee2, Szu-Chia Chen3,4,5,6
1Department of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Journal of Clinical Laboratory Analysis
|November 25, 2025
Summary
Hyperuricemia is independently linked to hyperlipidemia, a major cardiovascular disease risk factor. Managing serum uric acid levels is crucial for comprehensive cardiovascular risk reduction.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Public Health
Background:
- Hyperlipidemia is a primary risk factor for cardiovascular diseases (CVD).
- Hyperuricemia is increasingly recognized for its association with adverse cardiometabolic outcomes, including dyslipidemia.
- The combined impact of hyperuricemia and hyperlipidemia on cardiovascular risk necessitates further investigation.
Purpose of the Study:
- To investigate the association between hyperuricemia and hyperlipidemia.
- To identify hyperuricemia as an independent predictor of hyperlipidemia.
Main Methods:
- Analysis of data from 119,037 participants in the Taiwan Biobank.
- Comparison of baseline characteristics and metabolic profiles between participants with and without hyperuricemia.
- Application of univariate and multivariate logistic regression analyses to assess associations.
Main Results:
- Participants with hyperuricemia exhibited a more adverse cardiometabolic profile, including higher BMI, smoking, alcohol consumption, hypertension, and diabetes.
- Hyperuricemia was significantly associated with hyperlipidemia in univariate analysis (OR: 1.706).
- Hyperuricemia remained an independent predictor of hyperlipidemia in multivariate analysis (OR: 1.102).
Conclusions:
- Hyperuricemia is independently associated with hyperlipidemia.
- Serum uric acid management is important for mitigating cardiovascular disease risk.
- Findings emphasize comprehensive risk factor management for cardiovascular health.
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