Hyperuricemia Is Independently Associated With Hyperlipidemia in a Large Population-Based Study

Hyperlipidemia is a significant risk factor for cardiovascular diseases. Hyperuricemia has also been linked to adverse cardiometabolic outcomes, including dyslipidemia. The relationship between hyperuricemia and hyperlipidemia is of particular concern due to their combined impact on cardiovascular risk.

This study analyzed data from 119,037 participants in the Taiwan Biobank to explore the association between hyperuricemia and hyperlipidemia. The study compared baseline characteristics and metabolic profiles between participants with and without hyperuricemia. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with hyperlipidemia, focusing on hyperuricemia as an independent variable.

The participants with hyperuricemia had a more adverse cardiometabolic profile, including a higher body mass index (BMI), a higher prevalence of smoking and alcohol consumption, hypertension, and diabetes, and a worse lipid profile. Univariate analysis showed significant associations between hyperlipidemia and age, BMI, smoking history, alcohol consumption, hypertension, diabetes, and hyperuricemia (OR: 1.706, 95% CI: 1.625-1.791, p < 0.001). In multivariate analysis, hyperuricemia remained an independent predictor of hyperlipidemia (OR: 1.102, 95% CI: 1.041-1.165, p < 0.001), along with age, BMI, smoking, alcohol consumption, hypertension, diabetes, and a lower estimated glomerular filtration rate.

Hyperuricemia is independently associated with hyperlipidemia, underscoring its role in the complex interplay of metabolic factors contributing to cardiovascular disease risk. Our findings highlight the importance of comprehensive risk factor management incorporating serum uric acid to mitigate the impact of hyperlipidemia and associated cardiovascular conditions.