Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Ras Gene02:38

The Ras Gene

7.0K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.0K
Tumor Progression02:07

Tumor Progression

7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anorectal Melanoma Management Evolution: A Narrative Review.

Annali italiani di chirurgia·2026
Same author

Predicting Treatment Response After Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.

Annals of surgery·2026
Same author

Preliminary results of a prospective study on FAPi-PET for staging of locally advanced gastric cancer.

Updates in surgery·2026
Same author

Development of a Large Animal Rectovaginal Fistula Model.

Urogynecology (Philadelphia, Pa.)·2026
Same author

Intracorporeal Versus Extracorporeal Anastomosis in Crohn's Disease: Recurrence and Perioperative Outcomes After Minimally Invasive Ileocecectomy.

ANZ journal of surgery·2026
Same author

Robotic vs. laparoscopic redo ileocolonic resection for recurrent Crohn's disease.

Journal of robotic surgery·2026
Same journal

Reverse-Bevel (ProCore) EUS-Guided Fine-Needle Biopsy for Solid Pancreatic Mass Lesions: a GRADE-Assessed Systematic Review and Meta-Analysis of Prospective Randomized Trials.

Journal of gastrointestinal cancer·2026
Same journal

Outcomes of Epidermal Growth Factor Receptor Inhibitors in Locally Advanced and Metastatic Anal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Journal of gastrointestinal cancer·2026
Same journal

Comment on "MRI and PET-Based Machine Learning Radiomics for Metastasis Prediction in Pancreatic Ductal Adenocarcinoma: A Systematic Review".

Journal of gastrointestinal cancer·2026
Same journal

Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Patients with Esophageal Carcinoma: A Systematic Review and Meta-Analysis.

Journal of gastrointestinal cancer·2026
Same journal

The Impact of Tumor Volume Change Rate During Neoadjuvant Chemoradiotherapy-immunotherapy and of the Timing to Surgery on Prognosis in Patients with Esophageal Squamous Cell Carcinoma: A Multicenter Study.

Journal of gastrointestinal cancer·2026
Same journal

Prognostic Factors for Cancer-Specific Survival after Recurrence in Chemo-Naïve Stage I-III Colorectal Cancer.

Journal of gastrointestinal cancer·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.9K

Local Recurrence Rates in Locally Advanced Rectal Cancer Are Higher with KRAS Codon 13 Mutations.

Richard Sassun1,2, Annaclara Sileo1,2, Jyi Cheng Ng1

  • 1Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Journal of Gastrointestinal Cancer
|November 25, 2025
PubMed
Summary
This summary is machine-generated.

KRAS mutations in codon 13 are linked to local recurrences in rectal cancer. Preoperative genetic testing may improve risk stratification for locally advanced rectal cancer (LARC) patients.

Keywords:
KRASLocal recurrenceOncologic surgeryRectal cancer

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

631
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

475

Related Experiment Videos

Last Updated: Jan 10, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.9K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

631
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

475

Area of Science:

  • Oncology
  • Molecular Biology
  • Gastrointestinal Surgery

Background:

  • Local recurrence (LR) remains a challenge in rectal cancer treatment despite advances in surgical techniques like total mesorectal excision (TME).
  • Genetic mutations play a role in rectal cancer progression and recurrence.
  • The impact of KRAS mutations on LR in locally advanced rectal cancer (LARC) is not well understood.

Purpose of the Study:

  • To investigate the association between KRAS mutations and local recurrences (LR) in patients with locally advanced rectal cancer (LARC).
  • To determine if specific KRAS mutations are risk factors for LR in LARC.

Main Methods:

  • Retrospective analysis of LARC patients (2018-2023) comparing KRAS mutated and wild-type cohorts.
  • Propensity score matching was used to balance groups based on clinical factors and treatment.
  • Univariate Cox regression analyses assessed the influence of KRAS mutations on LR.

Main Results:

  • Out of 136 patients (68 KRAS mutated, 68 wild-type), the overall LR rate was 8.1%.
  • KRAS mutations in codon 13 (G13D/G13C) were significantly associated with increased LR risk (HR=7.06, p=0.001), with a 33.3% LR rate.
  • Other KRAS mutations did not show a significant association with LR.

Conclusions:

  • Codon 13 KRAS mutations may be a significant risk factor for local recurrence in LARC.
  • Findings require validation in larger studies due to the limited sample size.
  • Preoperative KRAS mutation testing could aid in risk stratification for LARC patients.