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Related Experiment Video

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FGF13 is not secreted from mouse neurons.

Mattia Malvezzi1, Haiying Zhang2, Patrick Towers1

  • 1Cardiovascular Research Institute, and.

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|November 25, 2025
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Summary

Fibroblast growth factor 13 (FGF13) does not appear to be secreted from cells. This finding challenges recent suggestions that FGF13 interacts with extracellular domains of neuronal voltage-gated sodium channels.

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Area of Science:

  • Molecular and Cellular Biology
  • Neuroscience

Background:

  • Fibroblast growth factor 13 (FGF13) is a noncanonical FGF.
  • FGF13 has been reported to regulate intracellularly voltage-gated sodium channels (VGSCs).
  • Recent studies propose FGF13 is secreted and interacts with extracellular domains of neuronal VGSCs.

Purpose of the Study:

  • To investigate the cellular localization and secretion of FGF13.
  • To determine if FGF13 interacts with extracellular domains of VGSCs.

Main Methods:

  • Transfection of FGF13 in a heterologous expression system.
  • Analysis of endogenous FGF13 secretion from cultured neurons.
  • Proximity labeling proteomics and other unbiased screens.

Main Results:

  • Transfected and endogenous FGF13 were not detected in the extracellular space.
  • FGF13 remains associated with cellular membranes.
  • Evidence suggests FGF13 is not available for direct interaction with extracellular protein domains.

Conclusions:

  • FGF13 is not secreted from cells.
  • The proposed mechanism of FGF13 regulating neuronal VGSCs via extracellular interactions is not supported by this data.
  • FGF13 likely functions intracellularly or within membranes.