Potent phenolics with antimigratory and anti-MRSA powers from fungus associated with Saussurea involucrata
Related Experiment Video
Updated: Jan 10, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Wei-Hua Yuan1, Meng-Ting Teng1, Lin Ma1
1School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
Abstract:
Seven phenolics were isolated from the endophytic fungus Alternaria sp. associated with Saussurea involucrata. The structures were identified as (±)-Dehydroaltenusin (1), Alterlactone (2), Altenuene (3), Djalonensone (4), 1-Deoxyrubralactone (5), Altertenuol (6), and Alternariol (7) respectively by a combination of spectroscopic and single-crystal X-ray diffraction analysis. Compound 1 showed obvious antimigratory activity against MCF-7 cells. Compound 2 showed potent antibacterial activities against a resistant bacterium Staphilococcus aureus 5 (MRSA). Meanwhile the cytotoxic, antioxidant were also evaluated.
Related Concept Videos
Gene Regulation in Microbial Communities: Quorum Sensing
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Chemical Agents for Microbial Control

