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Short-term outcomes of neonates with severe sepsis on intravenous colistin therapy - A prospective study

Shyna Soin1, Amanpreet Sethi2, Gurmeet Kaur3

  • 1Junior Resident, Department of Pediatrics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Tropical Doctor
|November 25, 2025
PubMed

Insights

Colistin therapy for severe neonatal sepsis showed 17.5% resistance in Gram-negative bacteria but minimal nephrotoxicity. This suggests colistin is a viable reserve antibiotic option for neonatal intensive care units facing high multidrug resistance (MDR).

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • High incidence of multidrug resistance (MDR) is a significant challenge in neonatal intensive care units (NICUs).
  • Severe sepsis in neonates requires effective antibiotic treatment, but rising MDR limits therapeutic options.

Purpose of the Study:

  • To evaluate the short-term outcomes of intravenous colistimethate sodium (Colistin) therapy in neonates with severe sepsis.
  • To assess the incidence of nephrotoxicity associated with Colistin use in this vulnerable population.

Main Methods:

  • Retrospective analysis of 135 neonates with severe sepsis treated with intravenous Colistin.
  • Evaluation of bacterial resistance patterns and clinical outcomes, including nephrotoxicity.

Main Results:

  • A resistance rate of 17.5% was observed among 57 Gram-negative bacterial isolates.
  • Colistin therapy was associated with minimal nephrotoxicity in the studied neonates.

Conclusions:

  • Colistin demonstrates a reasonable efficacy and safety profile as a reserve antibiotic in NICUs with high MDR.
  • The findings support the use of colistimethate sodium as a valuable option for treating severe neonatal sepsis when other antibiotics are ineffective.

Keywords:
ColistinNeonatesmultidrug resistancenephrotoxicitysepsis

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