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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Orthobiologics in 2025 and Beyond.

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    Orthobiologics enhance musculoskeletal healing. Established and novel therapies, including cell-based treatments, show promise for various conditions, with ongoing research and validation efforts.

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    Area of Science:

    • Orthobiologics
    • Musculoskeletal healing
    • Regenerative medicine

    Background:

    • Orthobiologics are biologic substances used to enhance healing and treat musculoskeletal conditions.
    • Established orthobiologics like platelet-rich plasma and bone marrow aspirate concentrate have decades of research but variable outcomes.
    • Novel orthobiologic therapies are emerging with recent regulatory approvals and future potential.

    Purpose of the Study:

    • To review current and future applications of orthobiologics.
    • To discuss established, novel, and emerging orthobiologic therapies.
    • To highlight the role of professional organizations in advancing orthobiologics.

    Main Methods:

    • Literature review of established and emerging orthobiologics.
    • Discussion of clinical applications and research findings.
    • Analysis of regulatory approvals and future trends.

    Main Results:

    • Established orthobiologics show variable outcomes despite extensive research.
    • Novel therapies like mesenchymal stem cells and cell-based implants show promise.
    • Perinatal cell-derived therapies represent a future frontier in orthobiologics.

    Conclusions:

    • Orthobiologics offer diverse therapeutic options for musculoskeletal pathologies.
    • Continued research, clinical validation, and collaboration are crucial for translating novel therapies.
    • Professional societies are key in guiding the development and application of orthobiologics.