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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...

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Related Experiment Video

Updated: Jun 19, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
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Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

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Limb Reconstruction in a Resource-Limited Environment.

Gamal Ahmed Hosny, Abdel-Hakim A Massoud, Ahmed Kholeif

    Instructional Course Lectures
    |November 25, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Limb reconstruction in resource-limited settings faces challenges due to high injury rates. New strategies and modified methods enable successful limb salvage, avoiding amputation even in complex cases.

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    Area of Science:

    • Orthopedic Surgery
    • Global Health
    • Trauma Surgery

    Background:

    • Limb reconstruction in resource-limited environments presents significant challenges.
    • High incidence of congenital deformities, trauma, war injuries, and post-traumatic complications in regions like the Middle East.
    • Amputation is often unacceptable to patients, necessitating limb salvage approaches.

    Purpose of the Study:

    • To discuss strategies for overcoming obstacles in limb reconstruction in resource-limited settings.
    • To present modified management methods and new classifications for complex limb injuries.
    • To achieve optimal patient outcomes through evidence-based, resource-conscious protocols.

    Main Methods:

    • Development of new classifications for limb deformities and injuries.
    • Modification of current management techniques to suit patient expectations and resource availability.
    • Case-by-case design of reconstruction methods based on extensive clinical experience.

    Main Results:

    • Successful limb salvage is achievable even in neglected and complex cases.
    • Reproducible protocols are being developed to improve outcomes in limb reconstruction.
    • Patient expectations can be met through tailored, evidence-based approaches.

    Conclusions:

    • Limb reconstruction in resource-limited areas requires innovative and adaptable strategies.
    • Modified management and new classifications are crucial for successful limb salvage.
    • A case-by-case approach, guided by scientific evidence and patient input, is essential for optimal results.