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Updated: Jan 10, 2026

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What Are Modifiable Risk Factors in Total Joint Arthroplasty? The Evidence.
Summary
Optimizing patients before total joint arthroplasty is key. However, high-quality evidence linking comorbidities like obesity to prosthetic joint infection as a modifiable risk is limited.
Area of Science:
- Orthopedic Surgery
- Evidence-Based Medicine
- Public Health
Background:
- Preoperative optimization and modifiable risk factors are crucial for improving total joint arthroplasty (TJA) outcomes.
- Existing clinical practice guidelines from major orthopedic associations lack high-quality evidence to classify comorbidities, such as obesity, as modifiable risks for prosthetic joint infection (PJI).
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