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A review of pretreatment and analytical methods for H2 receptor antagonists: An update since 2019
Yun-Qi Ning1, Yuan Zhang2, Wen-Hao Shao2
1Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Abstract:
H2 receptor antagonists (H2RAs) are widely used anti-secretory drugs that require careful therapeutic drug monitoring because of their dose-dependent hepatorenal toxicity risks. This review systematically examines recent advances (2019-present) in H2RA analysis, covering modern sample-preparation strategies such as on-chip dispersive liquid-liquid microextraction, ultrasound-assisted emulsification microextraction, novel materials-based solid-phase extraction, and modified QuEChERS techniques. In addition, cutting-edge detection platforms, including HPLC coupled with high-resolution mass detectors and various sensor-based methods, are discussed. Each method is assessed in terms of analytical performance, environmental impact, and practical applicability, while current limitations and future developmental needs are also highlighted. Taken together, this comprehensive comparison provides valuable insights for selecting suitable analytical approaches tailored to specific clinical or research requirements.
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