Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

923
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
923
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.7K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.7K
Modeling in Therapy01:26

Modeling in Therapy

366
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
366
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.7K
Socioemotional Development during Infancy01:30

Socioemotional Development during Infancy

411
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
411

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A decade of disease-modifying therapies for spinal muscular atrophy.

The Lancet. Child & adolescent health·2026
Same author

Early brain-penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1-related Aicardi-Goutières syndrome.

Clinical & translational immunology·2026
Same author

Boats on the rocks: Late prehistoric nautical iconography and landscape, from Northwest Iberia to Scandinavia.

PloS one·2026
Same author

The efficacy and safety of ketogenic diet therapy among adolescents and adults with drug resistant epilepsy: A systematic review and meta-analysis.

Seizure·2026
Same author

Strategic consensus on the clinical translation of advanced therapies in paediatric rare neurological disorders.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same author

Adaptive functioning in school-aged children with spinal muscular atrophy in the treatment era: a non-randomised cohort study.

The Lancet regional health. Western Pacific·2026

Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.8K

Behavioral and Emotional Challenges in Children With Spinal Muscular Atrophy.

Lakshmi Balaji1, Didu S Kariyawasam1, Karen Herbert2

  • 1Department of Neurology, Sydney Children's Hospital Randwick, Randwick, NSW, Australia; Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales, Sydney, NSW, Australia.

Pediatric Neurology
|November 25, 2025
PubMed
Summary
This summary is machine-generated.

Children with spinal muscular atrophy (SMA) often experience emotional and behavioral difficulties, impacting daily life. Early mental health screening and support are crucial for optimizing outcomes in these patients.

Keywords:
Behavioral outcomesEmotional well-beingHealth-related Quality-of-lifeHyperactivityPedsQL neuromuscular moduleSDQSpinal muscular atrophy

More Related Videos

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.4K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.8K

Related Experiment Videos

Last Updated: Jan 10, 2026

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.8K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.4K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.8K

Area of Science:

  • Neurology
  • Pediatrics
  • Genetics

Background:

  • Disease-modifying therapies have altered spinal muscular atrophy (SMA) progression, highlighting the need to understand its multisystem effects.
  • Cognitive and emotional processes are increasingly recognized as affected in SMA patients.

Purpose of the Study:

  • To determine the prevalence of behavioral and emotional issues in children with symptomatic SMA.
  • To characterize the specific emotional and behavioral profiles of these children.

Main Methods:

  • A single-center, cross-sectional study involving 48 children aged 4-17 years with symptomatic SMA.
  • Emotional and behavioral problems were assessed using the Strengths and Difficulties Questionnaire (SDQ).
  • Clinical data and quality of life outcomes (Pediatric Quality of Life neuromuscular module) were collected.

Main Results:

  • 35.4% of children with SMA showed difficulties on the SDQ, significantly higher than the general population (10%).
  • 60.4% had difficulties in at least one SDQ domain, with 25% experiencing issues with hyperactivity, emotional regulation, and conduct.
  • Emotional/behavioral difficulties were perceived as a burden by 33.3% of parents and were associated with lower quality of life.

Conclusions:

  • Children with SMA exhibit significant emotional and behavioral dysregulation across all motor function levels, negatively affecting daily life.
  • These challenges persist despite varying disease severity and treatment advancements.
  • Routine mental health surveillance and psychological support are recommended for early identification and intervention to improve health outcomes.