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Muscle-specific tyrosine kinase activation by a peptide-based dimerizer is orientation dependent

Fumiya Mizutani1, Kyoko Matoba1, Hayden Peacock2

  • 1Laboratory for Protein Synthesis and Expression, Institute for Protein Research, The University of Osaka, Suita 565-0871, Japan.

Structure (London, England : 1993)
|November 25, 2025
PubMed
Summary

Researchers identified a peptide that activates muscle-specific receptor tyrosine kinase (MuSK). This activation, dependent on receptor conformation, is crucial for neuromuscular junction formation and maintenance.

Keywords:
FcX-ray crystallographyacetylcholine receptor clusteringagrindimerizationmuscle-specifc kinaseneuromuscular junctionpeptidereceptor agonist

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