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Related Experiment Video

Updated: Jan 10, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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THE ASSOCIATION BETWEEN PERIODONTAL DISEASE AND STROKE RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Yuqing Zhang1, C E Bian1, Chaoran Yu1

  • 1Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.

The Journal of Evidence-Based Dental Practice
|November 25, 2025
PubMed
Summary

Periodontal disease significantly increases stroke risk by 72%. Effective dental biofilm control may reduce this risk, highlighting the importance of oral health for cerebrovascular prevention.

Keywords:
Cardiovascular diseaseCerebrovascular disorderGingivitisInflammationOral healthPeriodontitis

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Area of Science:

  • Cardiovascular Health
  • Oral Medicine
  • Epidemiology

Background:

  • Periodontal disease is a common inflammatory condition.
  • Stroke prevention is a major public health concern.
  • A potential link between periodontal disease and stroke risk exists.

Purpose of the Study:

  • To evaluate the association between periodontal disease and stroke risk.
  • To synthesize evidence from multiple studies on this relationship.

Main Methods:

  • Systematic review and meta-analysis following PRISMA 2020 guidelines.
  • Searched major databases (PubMed, EMBASE, Scopus, Web of Science, Cochrane Library) up to December 2024.
  • Assessed study quality using Newcastle-Ottawa Scale and pooled data with random-effects models.

Main Results:

  • Included 36 studies with over 7.6 million participants.
  • Periodontal disease was associated with a 72.4% increased stroke risk (OR: 1.724, 95% CI: 1.481-2.008).
  • Risk was elevated across diverse populations and for both ischemic and hemorrhagic strokes.

Conclusions:

  • Periodontal disease is an independent risk factor for stroke.
  • Oral hygiene and dental biofilm control may mitigate stroke risk.
  • Further research is needed to elucidate the underlying mechanisms.