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Published on: May 9, 2022
CLINICAL EFFECT OF LOCAL ALOE VERA USE AS AN ADJUNCT TO PERIODONTAL THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS
Chengzhi Xie1, Zhihui Jing2, Mingyu Xue2
1Department of Clinical Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Objectives:
Aloe Vera might be beneficial to improve periodontal condition. This systematic review and meta-analysis aimed to investigate Aloe Vera's clinical efficacy as an adjunct to scaling and root planning (SRP) for nonsurgical periodontal therapy.
Methods:
We included relevant randomized controlled trials (RCTs) comparing the effectiveness of Aloe Vera (I) with a (placebo) control (C) on periodontal parameters (O) in in adults with periodontitis (P) (registration number: CRD42022336946). PubMed, Cochrane Library, Embase, and Web of Science were searched. Mean difference (MD) with standard deviations of clinical outcomes were extracted and pooled from three studies.
Results:
Three studies were included in the systematic review and meta-analysis. Adjunctive Aloe Vera treatment reduced probing pocket depth (PPD), with MD = -0.47 (-0.78/-0.16) at 3 months, MD = -0.29 (-0.53/-0.06) at 6 months, and MD: -1.06 (-2.04/-0.08) at 12 months, compared to the control group. Overall differences for clinical attachment level (CAL) were found to be -0.56 (-0.85/-0.27) at 6 months and -0.98 (-1.28/-0.68) at 12 months, which indicated a statistically significant result favoring the test group over the control group. No significant differences were observed in reducing plaque index (PI), bleeding index (BI) at 6 months and CAL at 3 months in the local administration of Aloe Vera to SRP. Adjunctive Aloe Vera treatment reduced BI (MD: -0.40; -0.62/-0.18) at 12 months with respect to the control group.
Conclusions:
In comparison to SRP alone/placebo, the supplementary use of Aloe Vera in SRP results in improved periodontal treatment outcomes.
Limitations:
Limited by the quality and number of studies, the evidence was not reliable enough to support any clinical advice.
Clinical Significance:
The subgingival administration of Aloe Vera may be clinically efficacious for managing periodontal diseases.
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