Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

40.0K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.0K
Bacterial Transformation01:33

Bacterial Transformation

59.3K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.3K
The Central Dogma01:20

The Central Dogma

31.6K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
31.6K
Antibiotic Selection00:57

Antibiotic Selection

59.3K
Overview
59.3K
Reporter Genes02:11

Reporter Genes

12.9K
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
12.9K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

479
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
479

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNAGEN: A Generative Adversarial Network-Based Model to Generate Synthetic RNA Sequences to Target Proteins.

Chembiochem : a European journal of chemical biology·2026
Same author

Living Microbial Drugs.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

UTRGAN: learning to generate 5' UTR sequences for optimized translation efficiency and gene expression.

Bioinformatics advances·2025
Same author

Bacterial Living Therapeutics with Engineered Protein Secretion Circuits to Eliminate Breast Cancer Cells.

ACS synthetic biology·2024
Same author

An Antibiotic-Degrading Engineered Biofilm Platform to Combat Environmental Antibiotic Resistance.

ACS biomaterials science & engineering·2024
Same author

Screening Peptide Drug Candidates To Neutralize Whole Viral Agents: A Case Study with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

ACS pharmacology & translational science·2024
Same journal

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

Nature communications·2026
Same journal

PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.

Nature communications·2026
Same journal

Transient distortions of the South Atlantic Anomaly radiation environments driven by electric fields.

Nature communications·2026
Same journal

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.

Nature communications·2026
Same journal

Structural and mechanistic insights into primer synthesis initiation by DNA primase.

Nature communications·2026
Same journal

Changes in heritability and shared environmentality of educational attainment across twentieth-century Norway.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Bioluminescent Bacterial Imaging In Vivo
05:06

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

15.8K

Wireless in-body sensing through genetically engineered bacteria.

Ahmet Bilir1, Merve Yavuz2, Urartu Ozgur Safak Seker3,4

  • 1Electrical and Electronics Engineering Dept., Bogazici University, Istanbul, Turkey.

Nature Communications
|November 25, 2025
PubMed
Summary
This summary is machine-generated.

This study presents wireless implantable sensors using engineered cells to detect molecules. Bacterial activity degrades an antenna, enabling wireless communication without batteries or circuits for deep tissue monitoring.

More Related Videos

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.7K
Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
08:11

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Published on: July 6, 2013

13.3K

Related Experiment Videos

Last Updated: Jan 10, 2026

Bioluminescent Bacterial Imaging In Vivo
05:06

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

15.8K
Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.7K
Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
08:11

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

Published on: July 6, 2013

13.3K

Area of Science:

  • Biomedical Engineering
  • Synthetic Biology
  • Wireless Sensor Technology

Background:

  • Continuous molecular monitoring in vivo is crucial for diagnostics and therapeutics.
  • Existing implantable sensors face challenges with power supply and wireless communication through biological tissues.
  • Synthetic biology offers tools for cellular sensing, but integrating this with reliable wireless data transmission is complex.

Purpose of the Study:

  • To develop a battery-free, wireless implantable sensor system leveraging genetically engineered cells.
  • To overcome the challenge of electromagnetic signal attenuation in biological tissues for in-body communication.
  • To establish a method for converting cellular activity into detectable wireless signals for molecular sensing.

Main Methods:

  • Utilized genetically engineered Escherichia coli (E. coli) to sense specific molecules.
  • Harnessed cellular response to trigger the degradation of a passive microwave antenna.
  • Employed microwave backscatter communication to wirelessly monitor the antenna's state, indicating cellular activity.

Main Results:

  • Demonstrated a functional wireless link between a cell-based sensor and an external receiver.
  • Achieved molecular-level sensing at an implant depth of 25 mm within a human body phantom.
  • Successfully converted cellular activity into detectable electromagnetic signals without requiring batteries or integrated circuits.

Conclusions:

  • The developed cell-based sensor system offers a novel, battery-free approach for wireless in-body molecular monitoring.
  • This technology effectively bridges synthetic biology sensing with wireless communication for deep tissue applications.
  • Future implementations hold potential for coupling bacterial responses to a wide range of molecular targets for diverse sensing applications.