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Updated: Jan 10, 2026

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
08:50

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

Published on: April 18, 2025

855

Transcription factor FOXC2 regulates miR-145/ADAMTS5 axis to inhibit angiogenesis in hepatocellular carcinoma via

Jiangbei Yuan1, Zixiang Pan2, Fei Lv3

  • 1Center for General Practice Medicine, Department of Infectious Diseases, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China. yuanjiangbei@163.com.

BMC Cancer
|November 26, 2025
PubMed
Abstract

Insights

Circular RNA0002898 is downregulated in hepatocellular carcinoma (HCC), correlating with poor prognosis. Its suppression promotes HCC growth by affecting ADAMTS5 via miR-145, highlighting its potential as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • RNA Biology

Background:

  • Circular RNAs (circRNAs) are non-coding RNA molecules implicated in various cancers.
  • Their specific roles in hepatocellular carcinoma (HCC) remain largely undefined.
  • circRNAs are primarily found in the cytoplasm of eukaryotic cells.

Purpose of the Study:

  • To investigate the role and mechanism of cyclic RNA0002898 in hepatocellular carcinoma (HCC).
  • To explore the potential of cyclic RNA0002898 as a prognostic marker and therapeutic target in HCC.

Main Methods:

  • Quantified cyclic RNA0002898 expression in HCC tissues.
  • Investigated the regulation of cyclic RNA0002898 by forkhead box C2 (FOXC2).
  • Assessed the impact of cyclic RNA0002898 on HCC cell proliferation, migration, and invasion in vitro.
  • Elucidated the molecular mechanism involving miR-145 and ADAMTS5.

Main Results:

  • Cyclic RNA0002898 was found to be downregulated in HCC, associated with advanced tumor grade and reduced patient survival.
  • FOXC2 was identified as a regulator of cyclic RNA0002898 expression.
  • Reduced cyclic RNA0002898 levels enhanced HCC cell proliferation, migration, and invasion.
  • Cyclic RNA0002898 suppresses HCC growth by modulating ADAMTS5 levels through miR-145 antagonism, thereby inhibiting angiogenesis.

Conclusions:

  • Cyclic RNA0002898 plays a significant role in HCC pathogenesis.
  • Its downregulation is linked to poor prognosis and increased tumor aggressiveness.
  • Cyclic RNA0002898 represents a potential prognostic biomarker and therapeutic target for HCC.
Keywords:
AngiogenesisCircular RNAHepatocellular carcinomaMetastasisMicroRNATranscription factorsTumor growth

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